Miles Rowbottom (He/Him)

Miles' research primarily focuses upon the development of software and statistical models for the analysis of single-cell sequencing experiments. In particular, he is developing a R packages for use in downstream analysis of scSNV-seq^[1], a methodology that utilises a set of transcribed barcodes to improve the reliability of coupled single-cell DNA and transcriptomics.

In his research, Miles is collaborating with an Open Targets funded research group based out of the Sanger Institute - the NeuroImmune project^[2]. This research aims to identify the genetic predispositions and cellular mechanisms that underly the link between nervous system dysfunction and neurodegenerative disease. Through analysis of both patient samples and specifically-developed cell lines, the aim is to identify a range of targets for the development of precision medicine therapeutics. 

^[1] Cooper, S.E., Coelho, M.A., Strauss, M.E. et al. scSNV-seq: high-throughput phenotyping of single nucleotide variants by coupled single-cell genotyping and transcriptomics. Genome Biol 25, 20 (2024). https://doi.org/10.1186/s13059-024-03169-y

^[2] https://blog.opentargets.org/how-open-targets-bridges-academia-and-pharma/