Overview

Office: LSI building 5.10

Current funded PhD opportunities:

LSI PhD programme (http://www.exeter.ac.uk/livingsystems/research/lsiphdprogramme/):

Experimental and computational dissection of naive epiblast plasticity (with Austin Smith) Protein choreography at high spatiotemporal resolution: modelling the dynamics of enzyme regulation to predict drug behaviour (with JJ Phillips)

I am Associate Professor in Mathematics and academic lead for the Mathematics for health and life sciences group. My research is focussed on the development and use of mathematical and computational methods to help us understand the dynamics of complex biological systems, with a focus on problems in healthcare.

I study diverse biological systems ranging in spatial scales from cells to whole organs. Of particular interest are the dynamics of the brain, which fluctuate to give rise to evolving spatiotemporal patterns that can be significantly altered in disorders such as epilepsy. Using mathematical methods to uncover the mechanisms that govern these differences, and applying this knowledge to improve diagnosis and treatment, is an ongoing focus of my research. I am an affiliate of the EPSRC Hub for Quantitative Modelling in Healthcare and a co-investigator on the EPSRC Centre for Predictive Modelling in Healthcare.

Current group members:

Alessia Caccamo (PhD student)

Dom Dunstan (PhD student)

Mason Taylor (PhD student)

Ravi Poorun (Academic clinical lecturer)

Burhan Anis (MSci student)

Previous group members:

Dr. Lauric Ferrat

Dr. Joe Pinion

Dr. Arthur Spencer

Dr Marinho Lopes

Dr. Luke Tait

Dr Leandro Junges

Dr. Piotr Slowinski

Dr. Petroula Laiou

Dr Hossein Mohammadi

Dr Tanja Zerenner

Dr Kathryn Woodward

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Publications

_{Copyright Notice: Any articles made available for download are for personal use only. Any other use requires prior permission of the author and the copyright holder.}

| 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2014 | 2013 | 2012 | 2011 |

2023

• Karatas MD, Goodfellow M, Fieldsend JE. (2023) Exploring the Uncertainty of Approximated Fitness Landscapes via Gaussian Process Realisations, 2023 IEEE Symposium Series on Computational Intelligence (SSCI), DOI:10.1109/ssci52147.2023.10371950.
• Dunstan DM, Richardson MP, Abela E, Akman OE, Goodfellow M. (2023) Global nonlinear approach for mapping parameters of neural mass models, PLoS Comput Biol, volume 19, no. 3, DOI:10.1371/journal.pcbi.1010985. [PDF]

2022

• Spencer APC, Goodfellow M, Chakkarapani E, Brooks JCW. (2022) Resting-state functional connectivity in children cooled for neonatal encephalopathy, DOI:10.1101/2022.12.17.22283576. [PDF]
• Goodfellow M, Andrzejak RG, Masoller C, Lehnertz K. (2022) What Models and Tools can Contribute to a Better Understanding of Brain Activity?, Frontiers in Network Physiology, volume 2, DOI:10.3389/fnetp.2022.907995.
• Woodward K, Apps R, Goodfellow M, Cerminara NL. (2022) Cerebello-Thalamo-Cortical Network Dynamics in the Harmaline Rodent Model of Essential Tremor, Frontiers in Systems Neuroscience, volume 16, DOI:10.3389/fnsys.2022.899446.
• Spencer APC, Goodfellow M. (2022) Using deep clustering to improve fMRI dynamic functional connectivity analysis, Neuroimage, volume 257, DOI:10.1016/j.neuroimage.2022.119288. [PDF]
• Pinion J, Walsh C, Goodfellow M, Randall AD, Tyler CR, Winter MJ. (2022) Differential Electrographic Signatures Generated by Mechanistically-Diverse Seizurogenic Compounds in the Larval Zebrafish Brain, eNeuro, volume 9, no. 2, DOI:10.1523/ENEURO.0337-21.2022. [PDF]

2021

• Spencer APC, Goodfellow M. (2021) Using Deep Clustering to Improve fMRI Dynamic Functional Connectivity Analysis, DOI:10.1101/2021.12.14.472680.
• Spencer APC, Brooks JCW, Masuda N, Byrne H, Lee-Kelland R, Jary S, Thoresen M, Goodfellow M, Cowan FM, Chakkarapani E. (2021) Motor function and white matter connectivity in children cooled for neonatal encephalopathy, Neuroimage Clin, volume 32, DOI:10.1016/j.nicl.2021.102872. [PDF]
• Tait L, Lopes MA, Stothart G, Baker J, Kazanina N, Zhang J, Goodfellow M. (2021) A Large-Scale Brain Network Mechanism for Increased Seizure Propensity in Alzheimer’s Disease, DOI:10.1101/2021.01.19.427236.
• Spencer APC, Brooks JCW, Masuda N, Byrne H, Lee-Kelland R, Jary S, Thoresen M, Goodfellow M, Cowan FM, Chakkarapani E. (2021) Motor Function and White Matter Connectivity in Children Treated with Therapeutic Hypothermia for Neonatal Encephalopathy, DOI:10.1101/2021.04.30.21256369.
• Tait L, Lopes MA, Stothart G, Baker J, Kazanina N, Zhang J, Goodfellow M. (2021) A large-scale brain network mechanism for increased seizure propensity in Alzheimer’s disease, PLOS Computational Biology, volume 17, no. 8, pages e1009252-e1009252, DOI:10.1371/journal.pcbi.1009252. [PDF]
• Zerenner T, Goodfellow M, Ashwin P. (2021) Harmonic cross-correlation decomposition for multivariate time series, Physical Review E: Statistical, Nonlinear, and Soft Matter Physics, DOI:10.1103/PhysRevE.103.062213.
• Mohammadi H, Challenor P, Goodfellow M. (2021) Emulating complex dynamical simulators with random Fourier features. [PDF]
• Winter MJ, Pinion J, Tochwin A, Takesono A, Ball JS, Grabowski P, Metz J, Trznadel M, Tse K, Redfern WS. (2021) Functional brain imaging in larval zebrafish for characterising the effects of seizurogenic compounds acting via a range of pharmacological mechanisms, Br J Pharmacol, volume 178, no. 13, pages 2671-2689, DOI:10.1111/bph.15458. [PDF]
• Spencer APC, Brooks JCW, Masuda N, Byrne H, Lee-Kelland R, Jary S, Thoresen M, Tonks J, Goodfellow M, Cowan FM. (2021) Disrupted brain connectivity in children treated with therapeutic hypothermia for neonatal encephalopathy, NeuroImage: Clinical, volume 30, DOI:10.1016/j.nicl.2021.102582.
• Pandey R, Al-Nuaimi Y, Mishra RK, Spurgeon SK, Goodfellow M. (2021) Role of subnetworks mediated by TNF α , IL-23/IL-17 and IL-15 in a network involved in the pathogenesis of psoriasis, Scientific Reports, volume 11, no. 1, DOI:10.1038/s41598-020-80507-7.

2020

• Mohammadi H, Challenor P, Williamson D, Goodfellow M. (2020) Cross-validation based adaptive sampling for Gaussian process models, DOI:10.48550/arxiv.2005.01814.
• Spencer APC, Brooks JCW, Masuda N, Byrne H, Lee-Kelland R, Jary S, Thoresen M, Tonks J, Goodfellow M, Cowan FM. (2020) Structural Connectivity in Children Treated with Therapeutic Hypothermia for Neonatal Encephalopathy, DOI:10.1101/2020.09.23.20200014.
• Mohammadi H, Challenor P, Williamson D, Goodfellow M. (2020) Cross-validation based adaptive sampling for Gaussian process models, ASA Journal on Uncertainty Quantification, volume 10, pages 294-316. [PDF]
• Tait L, Tamagnini F, Stothart G, Barvas E, Monaldini C, Frusciante R, Volpini M, Guttmann S, Coulthard E, Brown JT. (2020) EEG microstate complexity for aiding early diagnosis of Alzheimer’s disease, Scientific Reports, volume 10, no. 1, article no. 17627, DOI:10.1038/s41598-020-74790-7. [PDF]
• Zaveri HP, Schelter B, Schevon CA, Jiruska P, Jefferys JGR, Worrell G, Schulze-Bonhage A, Joshi RB, Jirsa V, Goodfellow M. (2020) Controversies on the network theory of epilepsy: Debates held during the ICTALS 2019 conference, Seizure, volume 78, pages 78-85, DOI:10.1016/j.seizure.2020.03.010. [PDF]
• Lopes MA, Junges L, Woldman W, Goodfellow M, Terry JR. (2020) The Role of Excitability and Network Structure in the Emergence of Focal and Generalized Seizures, Frontiers in Neurology, volume 11, pages 74-74, DOI:10.3389/fneur.2020.00074. [PDF]

2019

• Bick C, Goodfellow M, Laing CR, Martens EA. (2019) Understanding the dynamics of biological and neural oscillator networks through exact mean-field reductions: a review, DOI:10.48550/arxiv.1902.05307.
• Laiou P, Avramidis E, Lopes MA, Abela E, Müller M, Akman OE, Richardson MP, Rummel C, Schindler K, Goodfellow M. (2019) Quantification and selection of ictogenic zones in epilepsy surgery, DOI:10.1101/602490.
• Tait L, Tamagnini F, Stothart G, Barvas E, Monaldini C, Frusciante R, Volpini M, Guttmann S, Coulthard E, Brown JT. (2019) EEG microstate complexity for aiding early diagnosis of Alzheimer’s disease, bioRxiv, pages 833244-833244, DOI:10.1101/833244. [PDF]
• Laiou P, Avramidis E, Lopes MA, Abela E, Müller M, Akman OE, Richardson MP, Rummel C, Schindler K, Goodfellow M. (2019) Quantification and Selection of Ictogenic Zones in Epilepsy Surgery, Frontiers in Neurology, volume 10, DOI:10.3389/fneur.2019.01045.
• Tait L. (2019) Multi-Scale Mathematical Modelling of Brain Networks in Alzheimer's Disease.
• Lopes MA, Perani S, Yaakub SN, Richardson MP, Goodfellow M, Terry JR. (2019) Revealing epilepsy type using a computational analysis of interictal EEG, Sci Rep, volume 9, no. 1, DOI:10.1038/s41598-019-46633-7. [PDF]
• Tait L, Stothart G, Coulthard E, Brown JT, Kazanina N, Goodfellow M. (2019) Network substrates of cognitive impairment in Alzheimer's Disease, Clin Neurophysiol, volume 130, no. 9, pages 1581-1595, DOI:10.1016/j.clinph.2019.05.027. [PDF]
• Słowiński P, Sheybani L, Michel CM, Richardson MP, Quairiaux C, Terry JR, Goodfellow M. (2019) Background EEG connectivity captures the time-course of epileptogenesis in a mouse model of epilepsy, eneuro, pages ENEURO.0059-ENEU19.2019, DOI:10.1523/ENEURO.0059-19.2019. [PDF]
• Junges L, Lopes MA, Terry JR, Goodfellow M. (2019) The role that choice of model plays in predictions for epilepsy surgery, Sci Rep, volume 9, no. 1, DOI:10.1038/s41598-019-43871-7. [PDF]
• Lopes MA, Goodfellow M, Terry JR. (2019) A Model-Based Assessment of the Seizure Onset Zone Predictive Power to Inform the Epileptogenic Zone, Frontiers in Computational Neuroscience, volume 13, DOI:10.3389/fncom.2019.00025. [PDF]
• Mohammadi H, Challenor P, Goodfellow M, Williamson D. (2019) Emulating computer models with step-discontinuous outputs using Gaussian processes. [PDF]
• Pinion J. (2019) Concordant spatio-temporal patterns of brain activation in zebrafish exposed to compounds with similar pharmacodynamics or with similar seizurogenic potential.
• Bick C, Goodfellow M, Laing CR, Martens EA. (2019) Understanding the dynamics of biological and neural oscillator networks through exact mean-field reductions: a review, Journal of Mathematical Neuroscience, 10(1):9, 2020. [PDF]
• Ferrat L. (2019) Machine Learning and Statistical Analysis of Complex Mathematical Models: An Application to Epilepsy.
• Mohammadi H, Challenor P, Goodfellow M. (2019) Emulating dynamic non-linear simulators using Gaussian processes, Computational Statistics and Data Analysis, volume 139, pages 178-196, DOI:10.1016/j.csda.2019.05.006.

2018

• Mohammadi H, Challenor P, Goodfellow M. (2018) Emulating dynamic non-linear simulators using Gaussian processes, DOI:10.48550/arxiv.1802.07575.
• Laiou P, Avramidis E, Lopes MA, Akman OE, Goodfellow M. (2018) Estimating Seizure Freedom Post-Surgery Using Mathematical Modelling, EPILEPSIA, volume 59, pages S204-S204. [PDF]
• Lopes M, Richardson M, Abela E, Rummel C, Schindler K, Goodfellow M, Terry J. (2018) A Computer Model Biomarker of Focal and Generalized Epilepsies from Resting State EEG, EPILEPSIA, volume 59, pages S58-S58. [PDF]
• Müller M, Schindler K, Goodfellow M, Pollo C, Rummel C, Steimer A. (2018) Evaluating resective surgery targets in epilepsy patients: A comparison of quantitative EEG methods, Journal of Neuroscience Methods, volume 305, pages 54-66, DOI:10.1016/j.jneumeth.2018.04.021.
• Tait L, Wedgwood K, Tsaneva-Atanasova K, Brown JT, Goodfellow M. (2018) Control of clustered action potential firing in a mathematical model of entorhinal cortex stellate cells, J Theor Biol, volume 449, pages 23-34, DOI:10.1016/j.jtbi.2018.04.013. [PDF]
• Ferrat LA, Goodfellow M, Terry JR. (2018) Classifying dynamic transitions in high dimensional neural mass models: A random forest approach, PLoS Computational Biology, volume 14, no. 3, DOI:10.1371/journal.pcbi.1006009.
• Lopes MA, Richardson MP, Abela E, Rummel C, Schindler K, Goodfellow M, Terry JR. (2018) Elevated Ictal Brain Network Ictogenicity Enables Prediction of Optimal Seizure Control, Frontiers in Neurology, volume 9, DOI:10.3389/fneur.2018.00098. [PDF]

2017

• Lopes MA, Richardson MP, Abela E, Rummel C, Schindler K, Goodfellow M, Terry JR. (2017) An optimal strategy for epilepsy surgery: Disruption of the rich-club?, PLoS Comput Biol, volume 13, no. 8, DOI:10.1371/journal.pcbi.1005637. [PDF]
• Goodfellow M, Rummel C, Abela E, Richardson MP, Schindler K, Terry JR. (2017) Computer models to inform epilepsy surgery strategies: Prediction of postoperative outcome, Brain, volume 140, no. 5, DOI:10.1093/brain/awx067.
• Pons AJ, Jedynak M, Garcia-Ojalvo J, Goodfellow M. (2017) Temporally correlated fluctuations drive epileptiform dynamics, NeuroImage, volume 146, pages 188-196, DOI:10.1016/j.neuroimage.2016.11.034.
• Oza HB, Pandey R, Roper D, Al-Nuaimi Y, Spurgeon SK, Goodfellow M. (2017) Modelling and finite-time stability analysis of psoriasis pathogenesis, International Journal of Control, volume 90, pages 1664-1677, article no. 8, DOI:10.1080/00207179.2016.1217566. [PDF]

2016

• Pons AJ, Jedynak M, Garcia-Ojalvo J, Goodfellow M. (2016) Identification of epileptogenic rhythms in a mesoscopic neuronal model, Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), volume 9886 LNCS.
• Phillips NE, Manning CS, Pettini T, Biga V, Marinopoulou E, Stanley P, Boyd J, Bagnall J, Paszek P, Spiller DG. (2016) Stochasticity in the miR-9/Hes1 oscillatory network can account for clonal heterogeneity in the timing of differentiation, eLife, volume 5, DOI:10.7554/elife.16118.
• Stothart G, Petkov G, Kazanina N, Goodfellow M, Tait L, Brown J. (2016) Graph-theoretical measures provide translational markers of large-scale brain network disruption in human dementia patients and animal models of dementia, International Journal of Psychophysiology, volume 108, pages 71-71, DOI:10.1016/j.ijpsycho.2016.07.232. [PDF]
• Schindler K, Rummel C, Andrzejak RG, Goodfellow M, Zubler F, Abela E, Wiest R, Pollo C, Steimer A, Gast H. (2016) Ictal time-irreversible intracranial EEG signals as markers of the epileptogenic zone, Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, volume 127, no. 9, pages 3051-3058, DOI:10.1016/j.clinph.2016.07.001.
• Schmidt H, Woldman W, Goodfellow M, Chowdhury FA, Koutroumanidis M, Jewell S, Richardson MP, Terry JR. (2016) A computational biomarker of idiopathic generalized epilepsy from resting state EEG, Epilepsia, volume 57, no. 10, pages e200-e204, DOI:10.1111/epi.13481.
• Goodfellow M, Rummel C, Abela E, Richardson MP, Schindler K, Terry JR. (2016) Estimation of brain network ictogenicity predicts outcome from epilepsy surgery, Scientific Reports, volume 6, DOI:10.1038/srep29215.
• Booth CA, Ridler T, Murray TK, Ward MA, de Groot E, Goodfellow M, Phillips KG, Randall AD, Brown JT. (2016) Electrical and Network Neuronal Properties Are Preferentially Disrupted in Dorsal, But Not Ventral, Medial Entorhinal Cortex in a Mouse Model of Tauopathy, J Neurosci, volume 36, no. 2, pages 312-324, DOI:10.1523/JNEUROSCI.2845-14.2016. [PDF]

2014

• Roper D, Al-nuaimi Y, Oza H, Goodfellow M, Spurgeon S. (2014) A systems biological model of chronic plaque psoriasis captures dynamics of known treatments, BRITISH JOURNAL OF DERMATOLOGY, volume 171, no. 6, pages E146-E146. [PDF]
• Petkov G, Goodfellow M, Richardson MP, Terry JR. (2014) A critical role for network structure in seizure onset: a computational modeling approach, Front Neurol, volume 5, DOI:10.3389/fneur.2014.00261. [PDF]
• Taylor PN, Wang Y, Goodfellow M, Dauwels J, Moeller F, Stephani U, Baier G. (2014) A computational study of stimulus driven epileptic seizure abatement, PLoS One, volume 9, no. 12, DOI:10.1371/journal.pone.0114316. [PDF]
• Wang Y, Goodfellow M, Taylor PN, Baier G. (2014) Dynamic mechanisms of neocortical focal seizure onset, PLoS Comput Biol, volume 10, no. 8, DOI:10.1371/journal.pcbi.1003787. [PDF]
• Goodfellow M, Phillips NE, Manning C, Galla T, Papalopulu N. (2014) microRNA input into a neural ultradian oscillator controls emergence and timing of alternative cell states, Nat Commun, volume 5, DOI:10.1038/ncomms4399. [PDF]
• Müller MF, Rummel C, Goodfellow M, Schindler K. (2014) Standing waves as an explanation for generic stationary correlation patterns in noninvasive EEG of focal onset seizures, Brain Connect, volume 4, no. 2, pages 131-144, DOI:10.1089/brain.2013.0192. [PDF]

2013

• Wang Y, Goodfellow M, Taylor PN, Garry DJ, Baier G. (2013) Computational modelling of microseizures and focal seizure onset, Recent Advance in Predicting and Preventing Epileptic Sezures, 83-98, DOI:10.1142/9789814525350_0006.
• Rummel C, Goodfellow M, Gast H, Hauf M, Amor F, Stibal A, Mariani L, Wiest R, Schindler K. (2013) A systems-level approach to human epileptic seizures, Neuroinformatics, volume 11, no. 2, pages 159-173, DOI:10.1007/s12021-012-9161-2. [PDF]
• Taylor PN, Goodfellow M, Wang Y, Baier G. (2013) Towards a large-scale model of patient-specific epileptic spike-wave discharges, Biol Cybern, volume 107, no. 1, pages 83-94, DOI:10.1007/s00422-012-0534-2. [PDF]
• Goodfellow M, Glendinning P. (2013) Mechanisms of intermittent state transitions in a coupled heterogeneous oscillator model of epilepsy, J Math Neurosci, volume 3, no. 1, DOI:10.1186/2190-8567-3-17. [PDF]

2012

• Baier G, Goodfellow M, Taylor PN, Wang Y, Garry DJ. (2012) SPATIO-TEMPORAL MODELS TO PREDICT AND CONTROL EPILEPTIC SEIZURE DYNAMICS, EPILEPSIA, volume 53, pages 20-20. [PDF]
• Wang Y, Goodfellow M, Taylor PN, Baier G. (2012) Phase space approach for modeling of epileptic dynamics, Physical Review E - Statistical, Nonlinear, and Soft Matter Physics, volume 85, no. 6, DOI:10.1103/PhysRevE.85.061918.
• Goodfellow M, Schindler K, Baier G. (2012) Self-organised transients in a neural mass model of epileptogenic tissue dynamics, Neuroimage, volume 59, no. 3, pages 2644-2660, DOI:10.1016/j.neuroimage.2011.08.060. [PDF]
• Al-Nuaimi Y, Goodfellow M, Paus R, Baier G. (2012) A prototypic mathematical model of the human hair cycle, J Theor Biol, volume 310, pages 143-159, DOI:10.1016/j.jtbi.2012.05.027. [PDF]
• Goodfellow M, Taylor PN, Wang Y, Garry DJ, Baier G. (2012) Modelling the role of tissue heterogeneity in epileptic rhythms, Eur J Neurosci, volume 36, no. 2, pages 2178-2187, DOI:10.1111/j.1460-9568.2012.08093.x. [PDF]
• Schindler K, Gast H, Goodfellow M, Rummel C. (2012) On seeing the trees and the forest: single-signal and multisignal analysis of periictal intracranial EEG, Epilepsia, volume 53, no. 9, pages 1658-1668, DOI:10.1111/j.1528-1167.2012.03588.x. [PDF]
• Baier G, Goodfellow M, Taylor PN, Wang Y, Garry DJ. (2012) The importance of modeling epileptic seizure dynamics as spatio-temporal patterns, Front Physiol, volume 3, DOI:10.3389/fphys.2012.00281. [PDF]
• Wang Y, Goodfellow M, Taylor PN, Baier G. (2012) Phase space approach for modeling of epileptic dynamics, Phys Rev E Stat Nonlin Soft Matter Phys, volume 85, no. 6 Pt 1, DOI:10.1103/PhysRevE.85.061918. [PDF]

2011

• Baier G, Goodfellow M, Taylor P, Wang Y. (2011) SPONTANEOUS SPIKE-WAVE DISCHARGES IN SPATIALLY EXTENDED MODELS OF EPILEPTIC DYNAMICS, EPILEPSIA, volume 52, pages 60-60. [PDF]
• Goodfellow M, Schindler K, Baier G. (2011) Intermittent spike-wave dynamics in a heterogeneous, spatially extended neural mass model, Neuroimage, volume 55, no. 3, pages 920-932, DOI:10.1016/j.neuroimage.2010.12.074. [PDF]

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